Panos Bitsios, MD/PhD
University of Crete
Tel: +30 2810 394610
Lab web page: http://bitsioslab.med.uoc.gr
1985 BS in Medicine, Aristotle University of Thessaloniki
1993 Certificate of Completion of Psychiatric Training
1997 PhD in Psychopharmacology, University of Nottingham
97-99 Postdoctoral Fellow, University of Nottingham
Translational research in psychiatry with a focus on developing and exploring valid translational paradigms in humans for research in the psychoses, affective processing in mood disorders, anxiety and arousal. We study (endo)phenotypes such as the prepulse inhibition of the acoustic startle response, aspects of cognition and the modulation of startle and the pupillary light reflexes by affective states, threat, and arousal. We investigate the genetic architecture of these phenotypes, their association with cognitive functions, personality dimensions and their response to pharmacological and psychological interventions in healthy subjects, high risk populations and patients. The central aim is to characterize these phenotypes, in the belief that learning about them will inform us on core pathophysiological dimensions and the neurobiology of psychosis and anxiety. We hope that this will aid psychiatric diagnosis, facilitate the development of customized treatments and ultimately improve patient care. A large part of this work is focused on the neurobiology and genetics of schizophrenia-spectrum disorders.
Onassis Institute and other private benefactors, General Secretariat of Research and Technology – GSRT,
Leonardo EU, Janssen-Cilag
Recent Publications or Selected Publications
Roussos P, Giakoumaki SG, Rogdaki M, Pavlakis S, Frangou S, Bitsios P (2008). Prepulse inhibition of the startle reflex in healthy males depends on the catechol O-methyltransferase Val158Met gene polymorphism. Psychological Medicine 38(11):1651-8.
Roussos P, Giakoumaki SG, Bitsios P (2009). Tolcapone effects on gating, working memory and mood interact with the synonymous COMT rs4818C/G polymorphism.Biol Psychiatry 66(11):997-1004.
Giakoumaki SG, Bitsios P, Frangou S, Roussos P, Aasen I, Galea A, Kumari V (2010).Low Baseline Startle and Deficient Affective Startle Modulation in Remitted Bipolar Disorder Patients and their Unaffected Siblings. Psychophysiology 47: 659-668.
Lencz T, Knowles E, Davies G, Guha S, Liewald DC, Starr JM, Djurovic S, Melle I, Sundet K, Christoforou A, Reinvang I, Mukherjee S, Derosse P, Lundervold A, Steen VM, John M, Espeseth T, Räikkönen K, Widen E, Palotie A, Eriksson JG, Giegling I, Konte B, Ikeda M, Roussos P, Giakoumaki S, Burdick KE, Payton A, Ollier W, Horan M, Donohoe G, Morris D, Corvin A, Gill M, Pendleton N, Iwata N, Darvasi A, Bitsios P, Rujescu D, Lahti J, Hellard SL, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK. Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT) (2014). Mol Psychiatry. 19(2):168-74.
Panos Roussos, Stella G Giakoumaki, Chrysoula Zouraki, John F Fullard, Vasiliki Eirini Karagiorga, Eva-Maria Tsapakis, Zoe Petraki, Larry J Siever, Todd Lencz, Anil Malhotra, Cleanthe Spanaki, Panos Bitsios. (2016). The Relationship of Common Risk Variants and Polygenic Risk for Schizophrenia to Sensorimotor Gating. Biological Psychiatry79(12):988-96.